Vice Rector's Biography

Vice Rector's Biography

Prof. Amnon Albeck

Prof. Albeck received the BSc degree from the Department of Chemistry at Bar Ilan University, and carried out his PhD research in the Department of Organic Chemistry at The Weizmann Institute of Science, under the supervision of Prof. Mudi Sheves. He was then a post-doctoral fellow with Prof. Robert H. Abeles in the Graduate Department of Biochemistry at Brandeis University, USA. Prof. Albeck joined the Department of Chemistry at Bar Ilan as a faculty member and the recipient of the Alon Fellowship for young investigators in 1990. He is currently a professor of chemistry, the head of the Julius Spokojny Bioorganic Chemistry Laboratory, and a member of the Marcus Center for Medicinal Chemistry at Bar Ilan.

Prof. Albeck’s research includes two main themes: enzyme catalytic mechanisms and inhibition, and organic synthesis of peptides and peptidomimetics. The mechanistic studies concentrate on proteolytic enzymes, deciphering their catalytic core structure, understanding their mode of catalysis at the molecular level, and elucidating their biological function and involvement in diseases. Another aspect of this research is the development of inhibitors to these enzymes, functioning as mechanistic probes and as the basis for the drug development. These studies are multidisciplinary, involving synthetic organic chemistry, biochemistry, enzymology, cellular biology and computational chemistry. Emphasis is given to the development of new computational methods for the study of enzyme mechanisms and new computer-assisted drug design (CADD) tools. The synthetic chemistry research at Prof. Albeck’s lab deals with the development of peptide-based transition-state analog inhibitors of proteolytic enzymes, and of novel peptidomimetic compounds. Those can be used as enzyme inhibitors and as multi-drugs carrying scaffolds for targeting and control release of drugs.

Prof. Albeck published some 70 scientific articles in peer-reviewer journals. He earned research grants from competitive granting agencies (ISF, BSF, NIH), Ministry of Industry and Commerce (MAGNET), and high-tech industries, and personal and institutional equipment grants. Prof. Albeck supervised close to 70 graduate and post-graduate students. He has been teaching a variety of undergraduate and graduate level courses in the fields of organic chemistry, biochemistry, undergraduate organic chemistry laboratory, and laboratory safety.

Click here for Prof. Albeck's faculty page.

Last modified: 02/11/2014